What is Amygdalin Powder ? What are the functions and effects of amygdalin? I believe that many people don't know it very well, so let me introduce to you what is amygdalin and the efficacy and function of amygdalin.
Amygdalin (from the Greek word "almond"), also known as amygdalin, is a toxic cyanogenic glycoside found in many plants but most notably in apricots, bitter almonds, apples, In the seeds of plants such as peaches and plums. It is a glycoside isolated from almond seeds in 1803 by Pierre-Jean Robic and A. F. Boutron-Charlard. Liebig and Wheeler studied this substance in 1830. Laetrile is also found in other Prunus species, including apricots and black cherries, as well as leaves, fruit and loquat pits. Ernst T. Krebs (Ernst T. Krebs) once named this substance "vitamin B17" and believed that it could treat cancer, but subsequent research proved that this substance did not have the above effects. Amygdalin is not considered a vitamin by academic circles because amygdalin does not fit the definition of a vitamin. Amygdalin, a common cyanogenic glycoside, is an active ingredient in the traditional Chinese medicine bitter almond. It is a derivative of α-hydroxynitrile. It has become a commonly used expectorant, antitussive, and auxiliary anticancer drug in medicine. Amygdalin is widely found in the seeds of loquat, apricot, peach, green plum, bayberry and other plants. Laetrile is formed by linking two molecules of glucose and one molecule of amygdalin.
Extraction method of amygdalin:
To extract amygdalin, you can heat almonds or almonds in ethanol, then evaporate the solvent, add ether, and you can get fine white amygdalin crystals. Liebig and Waller found that when amygdalin breaks down, three products are formed: sugar, benzaldehyde, and hydrocyanic acid. Subsequent studies showed that sulfuric acid catalyzed the breakdown of amygdalin into glucose, benzaldehyde, and hydrocyanic acid, while hydrochloric acid broke it down into mandelic acid, D-glucose, and ammonia. There are two kinds of decomposition of amygdalin under the catalysis of enzymes: maltase partially decomposes to generate D-glucose and mandelonitrile glucoside (C6H5CH(CN)O·C6H11O5), the isomer of phenylacetonitrile glucoside. Almond enzyme breaks it down into benzaldehyde, cyanide and two molecules of glucose. This reaction occurs in bitter almonds, producing free benzaldehyde and cyanide normally found in bitter almonds.
Efficacy and function of Amygdalin Powder:
1. Antitussive and antiasthmatic effects
After oral administration, amygdalin can be decomposed into hydrogen, cyanic acid and benzaldehyde in the body. Hydrocyanic acid can have a certain inhibitory effect on the respiratory center, making the breathing movement tend to be quiet and achieve the effect of antitussive and asthma relief. Laetrile can promote the synthesis of pulmonary surfactant and improve the pathological changes in animals with oleic acid type respiratory distress.
2. Anti-tumor effect
Amygdalin has good anti-tumor effect and is used as an auxiliary drug in the treatment of cancer. Using amygdalin preparations for the treatment of advanced cancer patients can improve symptoms and prolong survival. Amygdalin was used in the treatment of cancerous pleural effusion, and it was found that amygdalin can control and relieve cancerous pleural effusion to a certain extent. Laetrile was injected intraperitoneally at 300mg/kg, 400mg/kg, and 600mg/kg into transplanted liver cancer mice for 10-14 days, and the cure rates of liver cancer were 72%, 60.8%, and 61%, respectively. The content of cytochrome P2450 in hepatic microsomes of mice with transplanted liver cancer was significantly lower than that of normal mice. When amygdalin was administered for 10 days, the content of P-450 in mice whose tumor growth was inhibited reached normal levels. The inhibitory rate of amygdalin on cervical cancer JJC26 strain is 50%-70%. Amygdalin and the hydrocyanic acid and benzaldehyde produced by its hydrolysis have been proved to have anti-cancer effects in vitro. The sulfhydrylase in cancer cells is less than that of normal cells, so it has the ability to detoxify hydrocyanic acid released by the hydrolysis of amygdalin Poor, amygdalin plus benzaldehyde or amygdalin plus β2 glucosidase can significantly improve the anti-cancer effect. It has been found that anaerobic glycolysis of cancer cells is dominant, and the acidic environment formed by the product lactic acid is conducive to improving β2 glucosidase. Enzyme activity promotes amygdalin to hydrolyze more hydrocyanic acid and benzaldehyde in cancer cells to exert a stronger anticancer effect.
3. Effects on the digestive system
When amygdalin is decomposed by enzymes to form hydrocyanic acid, it also produces benzaldehyde, which can inhibit the activity of pepsin, thereby affecting digestive function. The pepsin hydrolyzate of the water-soluble part of almond was administered to carbon tetrachloride-treated rats at a dose of 500 mg/kg, and it was found that it could inhibit the increase of AST, ALT levels and hydroxyproline content, and inhibit the euglobulin Prolongation of dissolution time. Pathologically, the hydrolyzate of pepsin in the water-soluble part of almond can inhibit the hyperplasia of rat liver connective tissue, but it cannot inhibit the increase of rat AST and ALT levels caused by D-galactosamine
4. Other functions
Amygdalin can specifically inhibit the increase in blood sugar caused by alloxan, and the strength of the effect is related to the concentration of amygdalin in the blood. Laetrile also has anticoagulant effect. The hot plate method and acetic acid writhing method in mice confirmed that amygdalin has analgesic effect and has no tolerance; after the mice were given amygdalin, there was no vertical tail response and jumping response induced by allylmorphine. Intramuscular injection of amygdalin 15mg/mouse and 35mg/mouse can significantly promote the proliferation of mitogens to mouse spleen T lymphocytes. Quickly frozen sections of the right frontotemporal lobe of the rat brain were incubated and stained with cytochrome oxidase. The staining system was observed by a micro-television image measurement system, and the data was processed by a computer. The results showed that amygdalin can significantly improve cell The role of pigment oxidase activity. Laetrile can increase the activity of type I collagenase secreted by human kidney fibroblasts (KFB) in the optimal concentration range and action time, inhibit the proliferation of human kidney KFB and the expression of type I collagen, and promote the apoptosis of human kidney KFB . The joint effect of amygdalin and Cordyceps sinensis and primary monolayer culture in vitro to obtain rat fibrohepatic hepatocytes, monitoring by ELISA method shows that amygdalin and Cordyceps sinensis can significantly improve the synthesis and secretion of albumin in rat fibrohepatic hepatocytes. Inject 99Mtc-sodium phytate into mice or observe the effect of amygdalin on the phagocytosis of mouse liver cells or the activation of rDNA by the Ag-NOR method of liver tissue printing. There is a very obvious promotion effect.
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