What is Pyrroloquinoline Quinone Powder?
The main component of pyrroloquinoline quinone powder is pyrroloquinoline quinone (Pyrroloquinoline quinone), referred to as PQQ, which is a new prosthetic group with similar physiological functions to vitamins and widely exists in prokaryotes, plants and mammals, such as Fermented soybeans or natto, green peppers, kiwi fruit, parsley, tea leaves, papaya, spinach, celery, breast milk, etc.
PQQ is the prosthetic group of many enzymes, which is responsible for the function of transferring electrons, protons and chemical groups in enzymatic reactions, and can also stimulate the growth of microorganisms, the germination of plant pollen, and promote the growth of plants.
The biological functions of PQQ are mainly concentrated in two aspects. First, it can support the growth and development of mitochondria and stimulate the rapid growth of human cells; second, it has good antioxidant properties, which can help remove free radicals and reduce cell damage. These two functions make it powerful in brain health, cardiovascular health, and metabolic health. Because the body cannot synthesize PQQ on its own, it can be supplemented through dietary supplements, usually in powder form, prepared by microbial fermentation.
The common PQQ supplement products currently on the market are also mainly aimed at brain health, sleep aid, energy supplement, oral beauty, pregnancy aid, etc., and are often used in conjunction with various raw materials such as MNM, coenzyme Q10, ginkgo leaf extract, and PS.
Physiological efficacy and role of Pyrroloquinoline Quinone Powder:
1. Super antioxidant capacity:
PQQ has a strong ability to scavenge peroxides, and can effectively scavenge HO• (hydroxyl radicals) and O2•– (superoxide anion radicals), specifically reflected in: protecting mitochondria from oxidative damage; inhibiting lipid excess Oxidant; protect cardiomyocytes from ischemia-reperfusion injury; protect the redox site of NMDA receptor (N-methyl-D-aspartate receptor), thereby promoting the recovery of spinal cord injury and preventing brain ischemia Blood hypoxia, to avoid severe shock in animal models; at the same time, PQQ can also protect the heart from myocardial ischemia and myocardial infarction, these protective effects are attributed to the antioxidant capacity of PQQ (PQQ/PQQH2).
2. Liver protection:
PQQ can protect the liver against alcohol and carbon tetrachloride-induced liver damage and TAA-induced liver fibrosis.
3. Neuroprotective effect:
PQQ can improve the neuronal damage caused by the oxygen-glucose deprivation model, reduce the content change of Nissl bodies caused by D-galactose treatment, inhibit neuron degeneration, and weaken the nerve damage caused by β-amyloid protein Helps promote the secretion of neurotrophic factors. In addition, PQQ can also significantly improve the memory function of rats, and has obvious effects on memory retention and prevention of dementia.
4. Improve reproductive performance:
Primiparous female mice were given a PQQ-deprived diet. It was found that if the female mice lacked PQQ in their diet, they would show reproductive disorders. The phenomenon of infertility or cannibalism of newborn mice. If an appropriate amount of PQQ is supplemented at this time, the growth of the young mice, the fertility and behavior of the female mice will gradually become normal. In the case of feeding enough PQQ, the reproductive ability and litter size of the female mice were significantly higher than those of the control group.
5. The role of growth factors:
Dietary deprivation of PQQ in maternal female mice will lead to growth retardation and dysplasia in newborn mice; the lack of PQQ in the diet will also lead to a large decrease in the content of lysine oxidase in the skin of the mice, resulting in a decrease in the content of skin collagen and elastin. Cross-linking damage manifests as fragile and peeling skin, thinning hair, bowed body, arched back, severe abdominal bleeding and even death. Therefore, PQQ is an essential nutritional factor for animal growth and development. Sufficient PQQ supplementation to the mother offspring can significantly increase the body weight of the pups. In addition, the existence of PQQ has also been found in human milk, suggesting that PQQ plays a very important role in the growth and development of juvenile animals.
6. Anti-inflammatory function, enhance immune regulation of the body:
PQQ can scavenge ROS (reactive oxygen free radicals) and resist inflammatory damage caused by oxidative stress. Injecting PQQ before injecting carrageenan into mice can reduce the inflammatory response of mouse paw caused by carrageenan. Interleukin-2 (IL-2) levels in mice were significantly reduced when the diet was deficient in PQQ, and spleen cells responded better to mitogen A and lipopolysaccharide when PQQ was added. The addition of PQQ to parenteral nutrition can increase the number of lymphocytes in lymph nodes, as well as CD4+ and CD8+ cells in lymph nodes, and can restore the integrity of gut-related lymphoid organs to a certain extent.
In which fields is Pyrroloquinoline Quinone Powder applied?
Because the body cannot synthesize PQQ on its own, it can be supplemented through dietary supplements, usually in powder form, prepared by microbial fermentation. The recommended daily intake for adults is 20 mg or 0.3 mg per kg of body weight, except for pregnant or breastfeeding women. At present, PQQ supplements are mainly aimed at brain health, sleep aid, energy supplement, oral beauty, pregnancy aid, etc., and are often used in conjunction with various raw materials such as MNM, coenzyme Q10, ginkgo leaf extract, and PS.
When PQQ and coenzyme Q10 are used together, a certain synergistic effect can be obtained. Taking 10 to 20 mg of PQQ has been shown to provide some improvements in brain processing and memory in multiple animal and human studies, but combining it with coenzyme Q10 yields even greater benefits. PQQ is also often combined with NMN and used in various anti-aging supplements.
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